Exploring the biocombinatorial potential of benzoxazoles: generation of novel caboxamycin derivatives

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Exploring the biocombinatorial potential of benzoxazoles: generation of novel caboxamycin derivatives

BACKGROUND The biosynthesis pathway of benzoxazole compounds caboxamycin and nataxazole have been recently elucidated. Both compounds share one of their precursors, 3-hydroxyanthranilate (two units in the case of nataxazole). In addition, caboxamycin structure includes a salicylate moiety while 6-methylsalycilate is the third scaffold in nataxazole. Pathways cross-talk has been identified in ca...

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Caboxamycin biosynthesis pathway and identification of novel benzoxazoles produced by cross‐talk in Streptomyces sp. NTK 937

Streptomyces sp. NTK937, producer of benzoxazole antibiotic caboxamycin, produces in addition a methyl ester derivative, O-methylcaboxamycin. Caboxamycin cluster, comprising one regulatory and nine structural genes, has been delimited, and each gene has been individually inactivated to demonstrate its role in the biosynthetic process. The O-methyltransferase potentially responsible for O-methyl...

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ژورنال

عنوان ژورنال: Microbial Cell Factories

سال: 2017

ISSN: 1475-2859

DOI: 10.1186/s12934-017-0709-6